Routing tips for mixed-signal PCB that can't have normal isolation

You bet!

No, don’t add CAN style termination.

I’d still advise you to add series resistors close to the source of each signal. You probably don’t need them, but they’re easier to remove than to add later. Nothing magic to the value, but you can start at either 33 Ohms or 0 Ohms depending on how confident you feel :slight_smile: